Migraine remains a complex and often misunderstood neurological condition, impacting millions globally across diagnosis, treatment, and long-term management. As research and technology advance, new insights are emerging that could transform care pathways and improve outcomes for both patients and healthcare professionals. HRW Synapse, our in-house specialist neuroscience team, attended EAN Congress 2025. The team have identified three key insights for migraine awareness, alongside subconscious behavioural themes uncovered by HRW Shift, our in-house behavioural science experts. Patient Education and Tracking Digital tools like the Migraine Buddy app are helping patients better understand their condition by tracking attack frequency and triggers. Many users discover they experience migraines more often than they realised, which can influence treatment decisions and improve communication with healthcare providers. This kind of self-monitoring empowers patients and supports more personalised care. Medication Overuse Triptans remain a common acute treatment, but overuse can lead to medication overuse headache (MOH), worsening migraine progression. Education is critical for both patients and healthcare professionals on appropriate usage limits and when to consider preventive options like anti-CGRP therapies. Reducing reliance on acute medications is a key step in breaking the cycle of chronic migraine. PACAP Pathway Insight Recent research highlights the role of the PACAP pathway as a parallel contributor to migraine, independent of CGRP. This explains why some patients continue to experience migraines despite anti-CGRP treatment. Understanding PACAP’s involvement opens new avenues for therapy and reinforces the complexity of migraine pathophysiology, emphasising the need for individualised treatment strategies. Subconscious Behavioural Theme: Habits While the adoption of anti-CGRP therapies has been strong across many countries, both patients and clinicians have developed a reliance on acute treatments for years. These treatment habits are reinforced by routine, familiarity, and immediate relief, making it harder to shift toward preventive strategies, even when the evidence is strong. Shifting this mindset will require clear communication around the evolving treatment paradigm and the benefits of preventive approaches. Real-world case studies that highlight missed opportunities for earlier intervention can be powerful tools to drive behaviour change and reinforce the value of timely treatment adjustments. Want to collaborate on your next migraine project? Reach out to our neuroscience team at HRW_Synapse@hrwhealthcare.com Apply Now!